Category Archives: Bacteria

TB Hides In Bone Marrow

Michelle Fay Cortez writing in Bloomberg News reported on a study in “Science Translational Medicine.  Researchers said they have uncovered the first evidence of tuberculosis hiding in mesenchymal stem cells in the bone marrow of people treated for the disease.”

tb-bacteriaAccording to the article, “the bacteria’s hideout in the self-renewing cells, where they capitalize on protection from the body’s own immune system, may explain how the germs survive.”

This is disturbing news since these sequestered tuberculosis bacteria can be protected from drugs used to eradicate them.

This has important  implications for patients intending to go on biologic therapy for rheumatoid arthritis and other diseases.

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Bad Teeth= Bad RA

 

Mary Ann Moon writing in Rheumatology News  described a study comparing 31 patients with new-onset rheumatoid arthritis (RA), 34 patients with chronic RA, and 18 healthy controls.The study examined the relationship between bad dentition and rheumatoid arthritis.bad-teeth

The upshot?

The prevalence of severe periodontal disease was 75 % in patients with new-onset RA… just as much as the prevalence with long-standing RA and much higher than the prevalence in healthy controls (39%). The culprit?

Porphyromonas species bacteria.

The association between periodontal disease and RA has been written about a lot. This should be added to genetics and smoking as big risk factors for RA.

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Is inflammation responsible for disease?

Chronic inflammation appears to be the final common denominator for many conditions. And while there have been many advances in the treatment of multiple disorders, many people still cling to the hope that natural remedies might be as effective as prescription drugs.

So let’s start with the supposition that chronic inflammation is responsible for many illnesses.

A prime example is rheumatoid arthritis.  The chronicrheumatoid-arthritis-hand
inflammation from this disease affects not only joints but internal organs as well.

In addition, chronic inflammation is responsible for the marked increase in cardiovascular events such as heart attack and stroke seen in RA.

Gingival infection and inflammation has been linked to both
RA as well as atherosclerotic cardiovascular disease.

An excellent article was published on the anti-inflammatory effects of cilantro
in RA in the Indian Journal of Medical Research by The All India Institute of Medical Sciences (AIIMS) researchers..  Similar articles have been published on the role of turmeric (curcumin) and other spices such as boswellia, bromelain, garlic, and ginger.

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Gut bacteria increases rheumatoid arthritis risk

Mayo Clinic and University of Illinois at Urbana-Champaign researchers found bacteria that having too much of a certain kind of gut bacteria could increase the risk of getting rheumatoid arthritis.

The studies were done on mice engineered to have a gene that predisposes to rheumatoid arthritis. The researchers also found that female mice had a tripled risk of developing an autoimmune disease compared with male mice, which is like how women are more likely to develop rheumatoid arthritis than men.

Similar findings have been seen with periodontal disease and bacteria responsible for periodontal infections.

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