Category Archives: functional MRI

Brain Activity Changes In Rheumatoid Arthritis Patients Responding To Anti-TNF Therapy

Nancy Walsh writing in MedPage Today reported on a study which showed, patients with rheumatoid arthritis who responded to anti-tumor necrosis factor (TNF) treatment showed distinct differences in brain activity on functional MRI brain(fMRI) compared with nonresponders.

The study waspublished in Arthritis & Rheumatism. Researchers found that, “unlike nonresponders, TNF responders showed high signal intensity on fMRI in several areas of the brain at baseline, including the prefrontal cortex, the somatosensory cortex, and the insular cortex.” Also, “only patients who had this exaggerated brain activity at baseline had begun to show clinical responses one month later, with decreases in disease activity scores of 1.8 points compared with a decrease of only 0.2 points in nonresponders.”

Interesting how the brain works…

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