Category Archives: monosodium urate

Why does gout cause attacks?

Gout is a disease due to the abnormal metabolism of purines, a substance found in many foods. Purines are converted to uric acid.   When the concentration of uric acid in blood rises above 6.8mg/dl, there is deposition of monosodium urate crystals in the joint.

gout_0Sites where monosodium urate deposits occur are in areas where there is a relatively low core temperature.  This decreases the solubility of uric acid.  Examples of such sites are peripheral cooler joints like the feet, elbow bursa, and the helix of the ear.

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