Gout medicines and heart medicines conflict

Patients who take medications for both heart conditions as well as gout may have a problem with drug conflicts.

gout_0For example, thiazide diuretics cause an increase in serum uric acid.

Losartan (Cozaar) and fenofibrate (Tricor), often prescribed for cardiac patients have a dual effect.  While they block the reabsorption of uric acid in the kidney which causes serum uric acid levels to decrease, they are also metabolized by the cytochrome P450 enzymes in the liver.  The issue here is that gout drugs are also metabolized through this enzyme system and therefore their effectiveness may be decreased.

What’s a mother to do?

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